Long-term plasticity in identified hippocampal GABAergic interneurons in the CA1 area in vivo.
Brain Struct Funct
; 222(4): 1809-1827, 2017 May.
Article
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| MEDLINE
| ID: mdl-27783219
ABSTRACT
Long-term plasticity is well documented in synapses between glutamatergic principal cells in the cortex both in vitro and in vivo. Long-term potentiation (LTP) and -depression (LTD) have also been reported in glutamatergic connections to hippocampal GABAergic interneurons expressing parvalbumin (PV+) or nitric oxide synthase (NOS+) in brain slices, but plasticity in these cells has not been tested in vivo. We investigated synaptically-evoked suprathreshold excitation of identified hippocampal neurons in the CA1 area of urethane-anaesthetized rats. Neurons were recorded extracellularly with glass microelectrodes, and labelled with neurobiotin for anatomical analyses. Single-shock electrical stimulation of afferents from the contralateral CA1 elicited postsynaptic action potentials with monosynaptic features showing short delay (9.95 ± 0.41 ms) and small jitter in 13 neurons through the commissural pathway. Theta-burst stimulation (TBS) generated LTP of the synaptically-evoked spike probability in pyramidal cells, and in a bistratified cell and two unidentified fast-spiking interneurons. On the contrary, PV+ basket cells and NOS+ ivy cells exhibited either LTD or LTP. An identified axo-axonic cell failed to show long-term change in its response to stimulation. Discharge of the cells did not explain whether LTP or LTD was generated. For the fast-spiking interneurons, as a group, no correlation was found between plasticity and local field potential oscillations (1-3 or 3-6 Hz components) recorded immediately prior to TBS. The results demonstrate activity-induced long-term plasticity in synaptic excitation of hippocampal PV+ and NOS+ interneurons in vivo. Physiological and pathological activity patterns in vivo may generate similar plasticity in these interneurons.
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Base de dados:
MEDLINE
Assunto principal:
Potenciação de Longa Duração
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Depressão Sináptica de Longo Prazo
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Região CA1 Hipocampal
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Neurônios GABAérgicos
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Interneurônios
Limite:
Animals
Idioma:
En
Revista:
Brain Struct Funct
Assunto da revista:
CEREBRO
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Reino Unido