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A New Caged-Glutamine Derivative as a Tool To Control the Assembly of Glutamine-Containing Amyloidogenic Peptides.
Awad, Loay; Jejelava, Nino; Burai, Ritwik; Lashuel, Hilal A.
Afiliação
  • Awad L; College of Engineering, University of Dammam, P. O. Box 1982, Dammam, 31451, Saudi Arabia.
  • Jejelava N; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Ecole Polytechnique Fédérale de Lausanne, EPFL), 1015, Lausanne, Switzerland.
  • Burai R; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Ecole Polytechnique Fédérale de Lausanne, EPFL), 1015, Lausanne, Switzerland.
  • Lashuel HA; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Ecole Polytechnique Fédérale de Lausanne, EPFL), 1015, Lausanne, Switzerland.
Chembiochem ; 17(24): 2353-2360, 2016 Dec 14.
Article em En | MEDLINE | ID: mdl-27788286
We present the design, synthesis, and characterization of a novel photocaged glutamine derivative (modified on the side chain of glutamine), and describe its use in enhancing peptide stability and solubility. Our results demonstrate that this approach can be used to develop molecular switches to control the folding and ß-sheet formation of amyloidogenic peptides.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Glutamina Idioma: En Revista: Chembiochem Assunto da revista: BIOQUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Arábia Saudita
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Glutamina Idioma: En Revista: Chembiochem Assunto da revista: BIOQUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Arábia Saudita