[Ototoxicity of cisplatin in children with malignant diseases]. / Ototoxizität von Cisplatin bei Kindern mit malignen Erkrankungen.
Klin Padiatr
; 201(4): 316-21, 1989.
Article
em De
| MEDLINE
| ID: mdl-2779137
ABSTRACT
Ten out of 20 children with malignant diseases who received cisplatin in combination with other drugs developed hearing impairment primarily at the higher and rarely also at the lower frequencies. The CDDP-ototoxicity was found to be dose-related and irreversible. Audiometric abnormalities were symmetrical and bilateral. Two patients had symptomatic hearing impairment. Ototoxicity was more severe with higher individual and higher cumulative doses. CNS-irradiation increases the ototoxic effect of CDDP. Audiometric testing at the beginning of chemotherapy and during chemotherapy is important to find out preexisting disturbances of hearing function and to recognize early developing hearing loss.
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Base de dados:
MEDLINE
Assunto principal:
Protocolos de Quimioterapia Combinada Antineoplásica
/
Cisplatino
/
Perda Auditiva Neurossensorial
/
Neoplasias
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
De
Revista:
Klin Padiatr
Ano de publicação:
1989
Tipo de documento:
Article