Lack of the P2X<sub>7</sub> receptor protects against AMD-like defects and microparticle accumulation in a chronic oxidative stress-induced mouse model of AMD.

Carver, Kyle A; Lin, C M; Bowes Rickman, Catherine; Yang, Dongli

Lack of the P2X₇ receptor protects against AMD-like defects and microparticle accumulation in a chronic oxidative stress-induced mouse model of AMD.

Carver, Kyle A; Lin, C M; Bowes Rickman, Catherine; Yang, Dongli.

Afiliação

Carver KA; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA.
Lin CM; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA.
Bowes Rickman C; Department of Ophthalmology, Duke Eye Center, Duke University, Durham, NC 27710, USA; Department of Cell Biology, Duke University, Durham, NC 27710, USA.
Yang D; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA. Electronic address: dlyang@umich.edu.

Biochem Biophys Res Commun ; 482(1): 81-86, 2017 Jan 01.

Article em En | MEDLINE | ID: mdl-27810364

Assuntos

Micropartículas Derivadas de Células/metabolismo; Degeneração Macular/patologia; Degeneração Macular/fisiopatologia; Oxigênio/metabolismo; Receptores Purinérgicos P2X7/metabolismo; Superóxido Dismutase-1/metabolismo; Animais; Feminino; Masculino; Camundongos; Camundongos Knockout; Estresse Oxidativo; Estresse Fisiológico; Superóxido Dismutase-1/genética

Palavras-chave

AMD; Microparticle (MP); Oxidative stress; P2X(7) receptor; Retinal pigmented epithelium (RPE); Sod1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxigênio / Micropartículas Derivadas de Células / Receptores Purinérgicos P2X7 / Superóxido Dismutase-1 / Degeneração Macular Limite: Animals Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos

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