Corticosteroids for the management of severe intracranial hypertension in meningoencephalitis caused by Cryptococcus gattii: A case report and review.
J Mycol Med
; 27(1): 109-112, 2017 Mar.
Article
em En
| MEDLINE
| ID: mdl-27818191
ABSTRACT
Immune reconstitution inflammatory syndrome in meningitis caused by Cryptococcus gattii in immunocompetent patients after initiation of antifungal therapy appears to be the result of paradoxical antifungal treatment-induced clinical deterioration due to improved local immune responses to cryptococcal organisms. Recent anecdotal reports have suggested a favorable clinical response to corticosteroids in select patients with C. gattii central nervous system (CNS) infections. In this report, we describe a 65-year-old patient with meningoencephalitis caused by C. gattii who developed persistent intracranial hypertension and was successfully managed with antifungal therapy, repeated lumbar puncture and corticosteroids. Our observations suggest a possible benefit of dexamethasone in the management of select cases of C. gattii CNS infection with intracranial hypertension. Further studies are necessary to evaluate the long-term use of steroids in select patients with C. gattii with intracranial hypertension.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Meningite Criptocócica
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Corticosteroides
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Hipertensão Intracraniana
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Cryptococcus gattii
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Meningoencefalite
Limite:
Aged
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Humans
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Male
Idioma:
En
Revista:
J Mycol Med
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Brasil