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Dengue and West Nile Virus Transmission in Children and Adults in Coastal Kenya.
Vu, David M; Banda, Tamara; Teng, Crystal Y; Heimbaugh, Chelsea; Muchiri, Eric M; Mungai, Peter L; Mutuku, Francis M; Brichard, Julie; Gildengorin, Ginny; Borland, Erin M; Powers, Ann M; Kitron, Uriel; King, Charles H; LaBeaud, A Desiree.
Afiliação
  • Vu DM; Department of Pediatrics, Stanford University School of Medicine, Stanford, California. davidvu@stanford.edu.
  • Banda T; Center for Immunobiology and Vaccine Development, Children's Hospital Oakland Research Institute, Oakland, California.
  • Teng CY; Center for Immunobiology and Vaccine Development, Children's Hospital Oakland Research Institute, Oakland, California.
  • Heimbaugh C; Center for Immunobiology and Vaccine Development, Children's Hospital Oakland Research Institute, Oakland, California.
  • Muchiri EM; Division of Vector Borne and Neglected Tropical Diseases, Ministry of Health, Nairobi, Kenya.
  • Mungai PL; Case Western Reserve University, Cleveland, Ohio.
  • Mutuku FM; Emory University, Atlanta, Georgia.
  • Brichard J; Center for Immunobiology and Vaccine Development, Children's Hospital Oakland Research Institute, Oakland, California.
  • Gildengorin G; Center for Immunobiology and Vaccine Development, Children's Hospital Oakland Research Institute, Oakland, California.
  • Borland EM; Centers for Disease Control and Prevention, Fort Collins, Colorado.
  • Powers AM; Centers for Disease Control and Prevention, Fort Collins, Colorado.
  • Kitron U; Emory University, Atlanta, Georgia.
  • King CH; Case Western Reserve University, Cleveland, Ohio.
  • LaBeaud AD; Department of Pediatrics, Stanford University School of Medicine, Stanford, California.
Am J Trop Med Hyg ; 96(1): 141-143, 2017 Jan 11.
Article em En | MEDLINE | ID: mdl-27821697
Dengue virus (DENV) and West Nile virus (WNV) are important reemerging arboviruses that are under-recognized in many parts of Africa due to lack of surveillance. As a part of a study on flavivirus, alphavirus, and parasite exposure in coastal Kenya, we measured neutralizing antibody against DENV and, to evaluate assay specificity, WNV in serum samples that tested positive for serum anti-DENV IgG by enzyme-linked immunosorbent assay. Of 830 anti-DENV IgG-positive samples that were tested for neutralizing activity, 488 (58.8%) neutralized DENV and 94 (11.3%) neutralized WNV. Of children ≤ 10 years of age, 23% and 17% had serum neutralizing antibody to DENV and WNV, respectively, indicating that DENV and WNV transmission has occurred in this region within the past decade. The results suggest that ongoing DENV and WNV transmission continues on the coast of Kenya and supports a need for routine arboviral surveillance in the area to detect and respond to future outbreaks.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Febre do Nilo Ocidental / Dengue Limite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Humans / Infant / Middle aged País/Região como assunto: Africa Idioma: En Revista: Am J Trop Med Hyg Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Febre do Nilo Ocidental / Dengue Limite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Humans / Infant / Middle aged País/Região como assunto: Africa Idioma: En Revista: Am J Trop Med Hyg Ano de publicação: 2017 Tipo de documento: Article