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Association of ACTN3 polymorphisms with BMD, and physical fitness of elderly women.
Min, Seok-Ki; Lim, Seung-Taek; Kim, Chang-Sun.
Afiliação
  • Min SK; Department of Sport Science, Korea Institute of Sport Science (KISS), Republic of Korea.
  • Lim ST; Department of Sport Science, Korea Institute of Sport Science (KISS), Republic of Korea.
  • Kim CS; Department of Physical Education, Dongduk Women's University, Republic of Korea.
J Phys Ther Sci ; 28(10): 2731-2736, 2016 Oct.
Article em En | MEDLINE | ID: mdl-27821924
ABSTRACT
[Purpose] Association of ACTN3 polymorphism with bone mineral density and the physical fitness of elderly women is still unclear. Therefore, this study investigated the association between ACTN3 genotype and bone mineral density, and the physical fitness of elderly women. [Subjects and Methods] Sixty-eight elderly women (67.38 ± 3.68 years) were recruited at a Seongbuk-Gu (Seoul, Korea) Medical Service Public Health Center. Measurements of physical fitness included muscle strength, muscle endurance, flexibility, agility, balance and VO2max. Bone mineral density (BMD), upper limb muscle mass, lower limb muscle mass, percent body fat and body fat mass for the entire body were measured by dual-energy X-ray absorptiometry and an analyzer. Genotyping for the ACTN3 R577X (rs1815739) polymorphism was performed using the TaqMan approach. [Results] ACTN3 gene distribution of subjects were in the Hardy-Weinberg equilibrium (p=0.694). The relative bone mineral density trunk, pelvis and spine differed significantly among the ACTN3 genotypes. There were no significant differences among bone mineral densities of the head, arms, legs, ribs and total, but the RR genotype tended to be higher than other genotypes. Physical fitness was not significantly different among the ACTN3 genotypes. [Conclusion] These results suggest that ACTN3 gene polymorphisms could be used as one of the genetic determinants of bone mass in elderly women, and in particular, they indicate that individuals with the RR genotype have higher BMD and bone mineral composition.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Revista: J Phys Ther Sci Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Revista: J Phys Ther Sci Ano de publicação: 2016 Tipo de documento: Article