Clues from Crouzon: Insights into the potential role of growth factors in the pathogenesis of myelinated retinal nerve fibers.
J Curr Ophthalmol
; 28(4): 232-236, 2016 Dec.
Article
em En
| MEDLINE
| ID: mdl-27830211
ABSTRACT
PURPOSE:
We present a case of bilateral extensive peripapillary myelinated retinal nerve fibers (MRNF) in an individual with Crouzon syndrome, an inherited form of craniosynostosis caused by overactivation of fibroblast growth factor receptor 2. As a secondary aim, we examine the utility of optical coherence tomography (OCT) angiography for visualization of peripapillary vasculature obscured by myelination on other imaging modalities.METHODS:
A 24-year-old woman with Crouzon syndrome was evaluated for suspected optic neuritis in the right eye.RESULTS:
Funduscopic examination and photography revealed the incidental finding of bilateral extensive peripapillary MRNF. OCT angiography provided excellent visualization of peripapillary retinal vessels, which were partially obscured by myelination on other imaging modalities.CONCLUSIONS:
This association of Crouzon syndrome with bilateral peripapillary MRNF may lend insight into the developmental control of optic nerve myelination, the pathogenesis of MRNF, and the potential role of growth factors in these processes. Further, OCT angiography allowed for excellent blood vessel visualization in this case of MRNF.
Texto completo:
1
Base de dados:
MEDLINE
Tipo de estudo:
Etiology_studies
Idioma:
En
Revista:
J Curr Ophthalmol
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos