Complex Ancient Genetic Structure and Cultural Transitions in Southern African Populations.
Genetics
; 205(1): 303-316, 2017 01.
Article
em En
| MEDLINE
| ID: mdl-27838627
ABSTRACT
The characterization of the structure of southern African populations has been the subject of numerous genetic, medical, linguistic, archaeological, and anthropological investigations. Current diversity in the subcontinent is the result of complex events of genetic admixture and cultural contact between early inhabitants and migrants that arrived in the region over the last 2000 years. Here, we analyze 1856 individuals from 91 populations, comprising novel and published genotype data, to characterize the genetic ancestry profiles of 631 individuals from 51 southern African populations. Combining both local ancestry and allele frequency based analyses, we identify a tripartite, ancient, Khoesan-related genetic structure. This structure correlates neither with linguistic affiliation nor subsistence strategy, but with geography, revealing the importance of isolation-by-distance dynamics in the area. Fine-mapping of these components in southern African populations reveals admixture and cultural reversion involving several Khoesan groups, and highlights that Bantu speakers and Coloured individuals have different mixtures of these ancient ancestries.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estruturas Genéticas
/
População Negra
/
DNA Antigo
Limite:
Humans
País/Região como assunto:
Africa
Idioma:
En
Revista:
Genetics
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Reino Unido