Statistics of topological RNA structures.
J Math Biol
; 74(7): 1793-1821, 2017 06.
Article
em En
| MEDLINE
| ID: mdl-27853818
ABSTRACT
In this paper we study properties of topological RNA structures, i.e. RNA contact structures with cross-serial interactions that are filtered by their topological genus. RNA secondary structures within this framework are topological structures having genus zero. We derive a new bivariate generating function whose singular expansion allows us to analyze the distributions of arcs, stacks, hairpin- , interior- and multi-loops. We then extend this analysis to H-type pseudoknots, kissing hairpins as well as 3-knots and compute their respective expectation values. Finally we discuss our results and put them into context with data obtained by uniform sampling structures of fixed genus.
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Base de dados:
MEDLINE
Assunto principal:
RNA
/
Modelos Moleculares
Idioma:
En
Revista:
J Math Biol
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos