A potentially protective role of IL-18 Binding Protein in HIV-infected Long-Term Non-Progressors.
Cytokine
; 90: 96-99, 2017 02.
Article
em En
| MEDLINE
| ID: mdl-27863336
An imbalance between IL-18 and its antagonist, IL-18 Binding Protein, occurs in the circulation of HIV-infected individuals. We show here for the first time that HIV-infected Long Term Non-Progressors (LTNPs) do not develop this imbalance, and maintain normal levels of IL-18BP in the circulation. Their circulating levels of the antagonist correlate negatively with viral loads and show a positive trend with CD4+ T cells counts. The maintenance of normal production of IL-18BP may contribute, at least in part, to the ability of LTNPs to delay AIDS progression.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndrome da Imunodeficiência Adquirida
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HIV-1
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Peptídeos e Proteínas de Sinalização Intercelular
Limite:
Female
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Humans
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Male
Idioma:
En
Revista:
Cytokine
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Canadá