pH-dependent effects of bepridil on Ca2+-extrusion across rat heart sarcolemma.
Arch Int Pharmacodyn Ther
; 298: 90-5, 1989.
Article
em En
| MEDLINE
| ID: mdl-2787975
The inhibition by bepridil of ATP-dependent Ca2+-uptake and Na+/Ca2+-exchange was studied in isolated rat cardiac sarcolemmal vesicles over a pH range of 6.3 to 7.8. It was found that the protonated and deprotonated species of bepridil induced the same inhibition and no activation of these two transport systems. However, the intrinsic activities of both systems appeared to be strongly dependent on the pH.
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Base de dados:
MEDLINE
Assunto principal:
Pirrolidinas
/
Sarcolema
/
Bloqueadores dos Canais de Cálcio
/
Cálcio
/
Miocárdio
Limite:
Animals
Idioma:
En
Revista:
Arch Int Pharmacodyn Ther
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Holanda