Diverting CERT-mediated ceramide transport to mitochondria triggers Bax-dependent apoptosis.

Jain, Amrita; Beutel, Oliver; Ebell, Katharina; Korneev, Sergey; Holthuis, Joost C M

Jain, Amrita; Beutel, Oliver; Ebell, Katharina; Korneev, Sergey; Holthuis, Joost C M.

Afiliação

Jain A; Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabrück, Osnabrück D-49076, Germany.
Beutel O; Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabrück, Osnabrück D-49076, Germany.
Ebell K; Max-Planck-Institute for Molecular Cell Biology and Genetics, Dresden D-01307, Germany.
Korneev S; Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabrück, Osnabrück D-49076, Germany.
Holthuis JC; Molecular Cell Biology Division, Department of Biology/Chemistry, University of Osnabrück, Osnabrück D-49076, Germany.

J Cell Sci ; 130(2): 360-371, 2017 01 15.

Article em En | MEDLINE | ID: mdl-27888218

Assuntos

Apoptose; Ceramidas/metabolismo; Mitocôndrias/metabolismo; Proteínas Serina-Treonina Quinases/metabolismo; Proteína X Associada a bcl-2/metabolismo; Biocatálise; Transporte Biológico; Retículo Endoplasmático/metabolismo; Células HeLa; Humanos; Ligação Proteica; Transporte Proteico; Proteínas de Transporte Vesicular/metabolismo; Proteína Killer-Antagonista Homóloga a bcl-2/metabolismo

Palavras-chave

Bcl-2 proteins; Ceramide transfer protein; Cytochrome c; Endoplasmic reticulum; Membrane contact sites; Mitochondrial apoptosis; VAP receptor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ceramidas / Proteínas Serina-Treonina Quinases / Apoptose / Proteína X Associada a bcl-2 / Mitocôndrias Limite: Humans Idioma: En Revista: J Cell Sci Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Alemanha

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