Presynaptic neuromuscular transmission defect in the stiff person syndrome.
BMC Neurol
; 16(1): 249, 2016 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-27905901
ABSTRACT
BACKGROUND:
The stiff person syndrome (SPS) is a rare disorder characterized by muscular rigidity and stiffness. CASE PRESENTATIONS We describe an SPS patient presenting with longstanding fatigue and electrophysiological evidence of presynaptic neuromuscular transmission defect, who responded to administration of pyridostigmine. In contrast, no electrophysiolgical evidence of neuromuscular transmission defect was demonstrated in 2 other SPS patients without fatigue symptoms.CONCLUSIONS:
Our findings suggest that glutamic acid decarboxylase (GAD) antibodies may play a role in presynaptic neuromuscular transmission defect of SPS patients with fatigue.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Rigidez Muscular Espasmódica
/
Transmissão Sináptica
/
Fadiga
/
Glutamato Descarboxilase
/
Junção Neuromuscular
Tipo de estudo:
Etiology_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
BMC Neurol
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Singapura