Little effect of HSP90 inhibition on the quantitative wing traits variation in Drosophila melanogaster.
Genetica
; 145(1): 9-18, 2017 Feb.
Article
em En
| MEDLINE
| ID: mdl-27909948
ABSTRACT
Drosophila wings have been a model system to study the effect of HSP90 on quantitative trait variation. The effect of HSP90 inhibition on environmental buffering of wing morphology varies among studies while the genetic buffering effect of it was examined in only one study and was not detected. Variable results so far might show that the genetic background influences the environmental and genetic buffering effect of HSP90. In the previous studies, the number of the genetic backgrounds used is limited. To examine the effect of HSP90 inhibition with a larger number of genetic backgrounds than the previous studies, 20 wild-type strains of Drosophila melanogaster were used in this study. Here I investigated the effect of HSP90 inhibition on the environmental buffering of wing shape and size by assessing within-individual and among-individual variations, and as a result, I found little or very weak effects on environmental and genetic buffering. The current results suggest that the role of HSP90 as a global regulator of environmental and genetic buffering is limited at least in quantitative traits.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Variação Genética
/
Asas de Animais
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Proteínas de Choque Térmico HSP90
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Característica Quantitativa Herdável
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Drosophila melanogaster
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Genetica
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Japão