Switching substitution groups on the in-tether chiral centre influences backbone peptides' permeability and target binding affinity.
Org Biomol Chem
; 15(3): 541-544, 2017 Jan 18.
Article
em En
| MEDLINE
| ID: mdl-27929189
ABSTRACT
Different substitution groups on the in-tether chiral centre of chirality-induced helical peptides (CIH peptides) showed distinguishable effects on the peptides' cellular uptakes and binding affinities with the estrogen receptor α(ER-α). This study proves that in-tether chiral centres are a valuable modification site for constructing peptide ligands with preferable biophysical properties.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Receptor alfa de Estrogênio
Limite:
Humans
Idioma:
En
Revista:
Org Biomol Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
China