Modified Profile of Matrix Metalloproteinase 2 and 9 Production by Human Fallopian Tube Epithelial Cells After Infection In Vitro With Neisseria gonorrhoeae.
J Infect Dis
; 215(3): 452-455, 2017 02 01.
Article
em En
| MEDLINE
| ID: mdl-27932616
ABSTRACT
Epithelial shedding and scarring of fallopian tube mucosa are the main consequences of sexually transmitted Neisseria gonorrhoeae infection and probably involve an imbalance of host extracellular matrix components and their regulators such as matrix metalloproteinases (MMPs). In the current study, primary human fallopian tube epithelial cells were infected with N. gonorrhoeae, and MMP patterns were examined. Gonococcal infection induced a significant increase in secreted MMP-9 and an accumulation of cytoplasmic MMP-2 over time, but no significant MMP-3 or MMP-8 production was observed. Thus, MMP-9 in particular could play a role in tubal scarring in response to gonococcal infection.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Gonorreia
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Metaloproteinase 2 da Matriz
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Metaloproteinase 9 da Matriz
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Células Epiteliais
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Tubas Uterinas
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Neisseria gonorrhoeae
Limite:
Female
/
Humans
País/Região como assunto:
Europa
Idioma:
En
Revista:
J Infect Dis
Ano de publicação:
2017
Tipo de documento:
Article