Axial levodopa-induced dyskinesias and neuronal activity in the dorsal striatum.
Neuroscience
; 343: 240-249, 2017 02 20.
Article
em En
| MEDLINE
| ID: mdl-27956068
ABSTRACT
Levodopa-induced dyskinesias are abnormal involuntary movements that limit the effectiveness of treatments for Parkinson's disease. Although dyskinesias involve the striatum, it is unclear how striatal neurons are involved in dyskinetic movements. Here we record from striatal neurons in mice during levodopa-induced axial dyskinesias. We developed an automated 3-dimensional motion tracking system to capture the development of axial dyskinesias at â¼10ms resolution, and correlated these movements with neuronal activity of striatal medium spiny neurons and fast-spiking interneurons. The average firing rate of medium spiny neurons increased as axial dyskinesias developed, and both medium spiny neurons and fast-spiking interneurons were modulated around axial dyskinesias. We also found that delta field potential power increased in the striatum with dyskinesia, and that this increased delta power coupled with striatal neurons. Our findings provide insight into how striatal networks change as levodopa-induced dyskinesias develop, and suggest that increased medium spiny neuron firing, increased delta field potential power, and abnormal delta-coupling may be neurophysiological signatures of dyskinesias. These data could be helpful in understanding the role of the striatum in the pathogenesis of dyskinesias in Parkinson's disease.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Levodopa
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Corpo Estriado
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Discinesia Induzida por Medicamentos
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Neurônios
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Antiparkinsonianos
Limite:
Animals
Idioma:
En
Revista:
Neuroscience
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos