DNA replication and inter-strand crosslink repair: Symmetric activation of dimeric nanomachines?
Biophys Chem
; 225: 15-19, 2017 06.
Article
em En
| MEDLINE
| ID: mdl-27989548
ABSTRACT
Eukaryotic DNA replication initiation and the Fanconi anemia pathway of interstrand crosslink repair both revolve around the recruitment of a set of DNA-processing factors onto a dimeric protein complex, which functions as a loading platform (MCM and FANCI-FANCD2 respectively). Here we compare and contrast the two systems, identifying a set of unresolved mechanistic questions. How is the dimeric loading platform assembled on the DNA? How can equivalent covalent modification of both factors in a dimer be achieved? Are multicomponent DNA-interacting machines built symmetrically around their dimeric loading platform? Recent biochemical reconstitution studies are starting to shed light on these issues.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Reparo do DNA
/
Replicação do DNA
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biophys Chem
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Reino Unido