Silibinin ameliorates Aß25-35-induced memory deficits in rats by modulating autophagy and attenuating neuroinflammation as well as oxidative stress.
Neurochem Res
; 42(4): 1073-1083, 2017 Apr.
Article
em En
| MEDLINE
| ID: mdl-28004303
ABSTRACT
Alzheimer's disease (AD) is a progressive, neurodegenerative disease. Accumulating evidence suggests that inflammatory response, oxidative stress and autophagy are involved in amyloid ß (Aß)-induced memory deficits. Silibinin (silybin), a flavonoid derived from the herb milk thistle, is well known for its hepatoprotective activities. In this study, we investigated the neuroprotective effect of silibinin on Aß25-35-injected rats. Results demonstrated that silibinin significantly attenuated Aß25-35-induced memory deficits in Morris water maze and novel object-recognition tests. Silibinin exerted anxiolytic effect in Aß25-35-injected rats as determined in elevated plus maze test. Silibinin attenuated the inflammatory responses, increased glutathione (GSH) levels and decreased malondialdehyde (MDA) levels, and upregulated autophagy levels in the Aß25-35-injected rats. In conclusion, silibinin is a potential candidate for AD treatment because of its anti-inflammatory, antioxidant and autophagy regulating activities.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Silimarina
/
Autofagia
/
Peptídeos beta-Amiloides
/
Estresse Oxidativo
/
Transtornos da Memória
Limite:
Animals
Idioma:
En
Revista:
Neurochem Res
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
China