Association of Body Length with Ocular Parameters in Mice.
Optom Vis Sci
; 94(3): 387-394, 2017 03.
Article
em En
| MEDLINE
| ID: mdl-28005683
ABSTRACT
PURPOSE:
To determine the association between changes in body length with ocular refraction, corneal radii, axial length, and lens thickness in two different mouse strains.METHODS:
Body length, ocular refraction, corneal radii, axial length, and lens thickness were measured for two inbred mouse strains 129S1/SvJ (n = 7) and C57BL/6 J (n = 10) from 4 to 12 weeks of age. Body length, from tip of nose to base of tail, was obtained using a digital camera. Biometric parameters, corneal radii, and refractions were measured using spectral-domain optical coherence tomography, automated keratometry, and infrared photorefraction, respectively. A mixed-model ANOVA was performed to examine the changes in ocular parameters as a function of body length and strain in mice controlling for age, gender, and weight over time.RESULTS:
C57BL/6J mice had significantly longer body length (average body length at 10 weeks, 8.60 ± 0.06 cm) compared to 129S1/SvJ mice (8.31 ± 0.05 cm) during development (P < .001). C57BL/6J mice had significantly hyperopic refractions compared to 129S1/SvJ mice across age (mean refraction at 10 weeks, 129S1/SvJ +0.99 ± 0.44D vs. C57BL/6J +6.24 ± 0.38D, P < .001). Corneal radius of curvature, axial length, and lens thickness (except 10 weeks lens thickness) were similar between the two strains throughout the measurement. In the mixed-model ANOVA, changes in body length showed an independent and significant association with the changes in refraction (P = .002) and corneal radii (P = .016) for each mouse strain. No significant association was found between the changes in axial length (P = .925) or lens thickness (P = .973) as a function of body length and strain.CONCLUSIONS:
Changes in body length are significantly associated with the changes in ocular refraction and corneal radii in different mouse strains. Future studies are needed to determine if the association between body length and ocular refraction are related to changes in corneal curvature in mice.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Refração Ocular
/
Erros de Refração
/
Córnea
/
Tamanho Corporal
/
Comprimento Axial do Olho
/
Cristalino
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Optom Vis Sci
Assunto da revista:
OPTOMETRIA
Ano de publicação:
2017
Tipo de documento:
Article