Naphthofuranone derivatives and other constituents from Pachira aquatica with inhibitory activity on superoxide anion generation by neutrophils.
Fitoterapia
; 117: 16-21, 2017 Mar.
Article
em En
| MEDLINE
| ID: mdl-28012920
ABSTRACT
Two new naphthofuranone derivatives, 11-hydroxy-2-O-methylhibiscolactone A (1) and O-methylhibiscone D (2), have been isolated from the stems of Pachira aquatica, together with 18 known compounds (3-20). The structures of two new compounds were determined through spectroscopic and MS analyses. Among the isolated compounds, 11-hydroxy-2-O-methylhibiscolactone A (1), isohemigossylic acid lactone-7-methyl ether (4), gmelofuran (6), and 5-hydroxyauranetin (8) exhibited inhibition (IC50≤28.84µM) of superoxide anion generation by human neutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP).
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Superóxidos
/
Bombacaceae
/
Furanos
/
Anti-Inflamatórios
/
Neutrófilos
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Fitoterapia
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Taiwan