Multiple major histocompatibility complex class I genes in Asian anurans: Ontogeny and phylogeny.
Dev Comp Immunol
; 70: 69-79, 2017 05.
Article
em En
| MEDLINE
| ID: mdl-28027939
ABSTRACT
Amphibians, as the first terrestrial vertebrates, offer a window into early major histocompatibility complex (MHC) evolution. We characterized the MHC class I of two Korean amphibians, the Asiatic toad (Bufo gargarizans) and the Japanese tree frog (Hyla japonica). We found at least four transcribed MHC class I (MHC I) loci, the highest number confirmed in any anuran to date. Furthermore, we identified MHC I transcripts in terrestrial adults, and possibly in aquatic larvae, of both species. We conducted a phylogenetic analysis based on MHC I sequence data and found that B. gargarizans and H. japonica cluster together in the superfamily Nobleobatrachia. We further identified three supertypes shared by the two species. Our results reveal substantial variation in the number of MHC I loci in anurans and suggest that certain supertypes have particular physiochemical properties that may confer pathogen resistance.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Anuros
/
Antígenos de Histocompatibilidade Classe I
/
Proteínas de Anfíbios
Tipo de estudo:
Prognostic_studies
Limite:
Animals
País/Região como assunto:
Asia
Idioma:
En
Revista:
Dev Comp Immunol
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Coréia do Sul