Loss of Nrf2 exacerbates the visual deficits and optic neuritis elicited by experimental autoimmune encephalomyelitis.

Larabee, Chelsea M; Desai, Shruti; Agasing, Agnieshka; Georgescu, Constantin; Wren, Jonathan D; Axtell, Robert C; Plafker, Scott M

Larabee, Chelsea M; Desai, Shruti; Agasing, Agnieshka; Georgescu, Constantin; Wren, Jonathan D; Axtell, Robert C; Plafker, Scott M.

Afiliação

Larabee CM; Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK.
Desai S; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK.
Agasing A; Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK.
Georgescu C; Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK.
Wren JD; Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK.
Axtell RC; Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK.
Plafker SM; Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK.

Mol Vis ; 22: 1503-1513, 2016.

Article em En | MEDLINE | ID: mdl-28050123

Assuntos

Encefalomielite Autoimune Experimental/complicações; Encefalomielite Autoimune Experimental/patologia; Fator 2 Relacionado a NF-E2/deficiência; Neurite Óptica/complicações; Neurite Óptica/patologia; Acuidade Visual; Animais; Citocinas/metabolismo; Encefalomielite Autoimune Experimental/fisiopatologia; Feminino; Inflamação/patologia; Masculino; Camundongos Endogâmicos C57BL; Camundongos Knockout; Fator 2 Relacionado a NF-E2/metabolismo; Nervo Óptico/patologia; Neurite Óptica/fisiopatologia; Paralisia/patologia; Células Ganglionares da Retina/metabolismo; Células Ganglionares da Retina/patologia; Caracteres Sexuais; Baço/patologia; Células Th1/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acuidade Visual / Neurite Óptica / Encefalomielite Autoimune Experimental / Fator 2 Relacionado a NF-E2 Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Mol Vis Assunto da revista: BIOLOGIA MOLECULAR / OFTALMOLOGIA Ano de publicação: 2016 Tipo de documento: Article

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