Use of common carp (Cyprinus carpio) and Aeromonas salmonicida for detection of immunomodulatory effects of chemicals on fish.
Mar Pollut Bull
; 124(2): 710-713, 2017 Nov 30.
Article
em En
| MEDLINE
| ID: mdl-28063699
ABSTRACT
To develop a test for assessing the immunomodulatory effects of chemical pollutants on fish, we evaluated the effects of dexamethasone on the natural host-pathogen interaction between common carp (Cyprinus carpio) and Aeromonas salmonicida. Carp were exposed to 1mgL-1 dexamethasone for the entire experimental period. One week after the exposure test started, the exposed fish, as well as unexposed fish, were bath-infected with A. salmonicida. One hundred percent mortality was observed in bacteria-infected fish exposed to dexamethasone, whereas no infection-associated mortality was observed in infected fish in the absence of dexamethasone exposure. In a separate experiment, dexamethasone exposure significantly suppressed hemolytic complement activity in bacteria-infected fish. These results clearly indicate that exposure to a high concentration of dexamethasone suppressed the carp immune system and caused subsequent mortality. Thus, this proposed test method is likely to be useful for evaluating the immunomodulatory effects of chemicals in fish.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Carpas
/
Dexametasona
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Infecções por Bactérias Gram-Negativas
/
Testes de Toxicidade
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Aeromonas salmonicida
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Doenças dos Peixes
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Imunossupressores
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Mar Pollut Bull
Ano de publicação:
2017
Tipo de documento:
Article