The key residue within the second extracellular loop of human EP3 involved in selectively turning down PGE<sub>2</sub>- and retaining PGE<sub>1</sub>-mediated signaling in live cells.

Akasaka, Hironari; Thaliachery, Natasha; Zheng, Xianghai; Blumenthal, Marissa; Nikhar, Sameer; Murdoch, Emma E; Ling, Qinglan; Ruan, Ke-He

The key residue within the second extracellular loop of human EP3 involved in selectively turning down PGE₂- and retaining PGE₁-mediated signaling in live cells.

Akasaka, Hironari; Thaliachery, Natasha; Zheng, Xianghai; Blumenthal, Marissa; Nikhar, Sameer; Murdoch, Emma E; Ling, Qinglan; Ruan, Ke-He.

Afiliação

Akasaka H; Center for Experimental Therapeutics and Pharmacoinformatics and Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, TX 77204-5037, USA.
Thaliachery N; Center for Experimental Therapeutics and Pharmacoinformatics and Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, TX 77204-5037, USA.
Zheng X; Center for Experimental Therapeutics and Pharmacoinformatics and Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, TX 77204-5037, USA.
Blumenthal M; Center for Experimental Therapeutics and Pharmacoinformatics and Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, TX 77204-5037, USA.
Nikhar S; Center for Experimental Therapeutics and Pharmacoinformatics and Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, TX 77204-5037, USA.
Murdoch EE; Center for Experimental Therapeutics and Pharmacoinformatics and Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, TX 77204-5037, USA.
Ling Q; Center for Experimental Therapeutics and Pharmacoinformatics and Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, TX 77204-5037, USA.
Ruan KH; Center for Experimental Therapeutics and Pharmacoinformatics and Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, TX 77204-5037, USA.

Arch Biochem Biophys ; 616: 20-29, 2017 02 15.

Article em En | MEDLINE | ID: mdl-28065721

Assuntos

Alprostadil/química; Dinoprostona/química; Receptores de Prostaglandina E Subtipo EP3/química; Receptores de Prostaglandina E Subtipo EP3/genética; Sítios de Ligação; Sinalização do Cálcio; Cristalografia por Raios X; DNA Complementar/química; Células HEK293; Humanos; Ligantes; Espectroscopia de Ressonância Magnética; Mutagênese Sítio-Dirigida; Mutação; Ligação Proteica; Domínios Proteicos; Receptores Adrenérgicos beta 2/química; Proteínas Recombinantes/química; Transdução de Sinais

Palavras-chave

EP selectivity; G protein-coupled receptor (GPCR); Prostaglandin; Prostaglandin E1; Prostaglandin E2; Receptor regulation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Alprostadil / Dinoprostona / Receptores de Prostaglandina E Subtipo EP3 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Arch Biochem Biophys Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos

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