Altered myocyte contractility and calcium homeostasis in alpha-myosin heavy chain point mutations linked to familial dilated cardiomyopathy.

Klos, Matthew; Mundada, Lakshmi; Banerjee, Indroneal; Morgenstern, Sherry; Myers, Stephanie; Leone, Michael; Kleid, Mark; Herron, Todd; Devaney, Eric

Klos, Matthew; Mundada, Lakshmi; Banerjee, Indroneal; Morgenstern, Sherry; Myers, Stephanie; Leone, Michael; Kleid, Mark; Herron, Todd; Devaney, Eric.

Afiliação

Klos M; Department of Pediatric Cardiac Surgery, UH Hospitals Cleveland, Cleveland, OH 44106, USA.
Mundada L; Department of Internal Medicine, Cardiovascular Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI 48108, USA.
Banerjee I; Department of Medicine, University of California, San Diego, CA 92103, USA.
Morgenstern S; Department of Pediatric Cardiac Surgery, UH Hospitals Cleveland, Cleveland, OH 44106, USA.
Myers S; Department of Medicine, University of California, San Diego, CA 92103, USA.
Leone M; Department of Medicine, University of California, San Diego, CA 92103, USA.
Kleid M; Department of Medicine, University of California, San Diego, CA 92103, USA.
Herron T; Department of Internal Medicine, Cardiovascular Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI 48108, USA.
Devaney E; Department of Pediatric Cardiac Surgery, UH Hospitals Cleveland, Cleveland, OH 44106, USA. Electronic address: Eric.Devaney@uhhospitals.org.

Arch Biochem Biophys ; 615: 53-60, 2017 02 01.

Article em En | MEDLINE | ID: mdl-28088328

Assuntos

Cálcio/metabolismo; Células Musculares/citologia; Cadeias Pesadas de Miosina/genética; Animais; Cardiomiopatia Dilatada; Homeostase; Humanos; Hipertrofia; Isoproterenol/química; Cinética; Masculino; Mutagênese; Contração Miocárdica; Miócitos Cardíacos/metabolismo; Cadeias Pesadas de Miosina/metabolismo; Fenótipo; Mutação Puntual; Ratos; Ratos Sprague-Dawley; Proteínas Recombinantes/metabolismo; Sarcômeros/metabolismo; Miosinas Ventriculares/metabolismo

Palavras-chave

Alpha myosin heavy chain (αMHC); Beta myosin heavy chain (ßMHC); Dilated cardiomyopathy (DCM); Hypertrophic cardiomyopathy (HCM); Isoproterenol (Iso)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cálcio / Cadeias Pesadas de Miosina / Células Musculares Limite: Animals / Humans / Male Idioma: En Revista: Arch Biochem Biophys Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos

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