Your browser doesn't support javascript.
loading
Teratomas of the cranial vault: a systematic analysis of clinical outcomes stratified by histopathological subtypes.
Lagman, Carlito; Bui, Timothy T; Voth, Brittany L; Chung, Lawrance K; Seo, David J; Duong, Courtney; Libowitz, Mark R; Walker, Naomi E; Nagasawa, Daniel T; Yang, Isaac.
Afiliação
  • Lagman C; Department of Neurosurgery, University of California, Los Angeles, 300 Stein Plaza, Los Angeles, 90095-1761, CA, USA.
  • Bui TT; Department of Neurosurgery, University of California, Los Angeles, 300 Stein Plaza, Los Angeles, 90095-1761, CA, USA.
  • Voth BL; Department of Neurosurgery, University of California, Los Angeles, 300 Stein Plaza, Los Angeles, 90095-1761, CA, USA.
  • Chung LK; Department of Neurosurgery, University of California, Los Angeles, 300 Stein Plaza, Los Angeles, 90095-1761, CA, USA.
  • Seo DJ; Department of Neurosurgery, University of California, Los Angeles, 300 Stein Plaza, Los Angeles, 90095-1761, CA, USA.
  • Duong C; Department of Neurosurgery, University of California, Los Angeles, 300 Stein Plaza, Los Angeles, 90095-1761, CA, USA.
  • Libowitz MR; Department of Neurosurgery, University of California, Los Angeles, 300 Stein Plaza, Los Angeles, 90095-1761, CA, USA.
  • Walker NE; Department of Neurosurgery, University of California, Los Angeles, 300 Stein Plaza, Los Angeles, 90095-1761, CA, USA.
  • Nagasawa DT; Department of Neurosurgery, University of California, Los Angeles, 300 Stein Plaza, Los Angeles, 90095-1761, CA, USA.
  • Yang I; Department of Neurosurgery, University of California, Los Angeles, 300 Stein Plaza, Los Angeles, 90095-1761, CA, USA. iyang@mednet.ucla.edu.
Acta Neurochir (Wien) ; 159(3): 423-433, 2017 03.
Article em En | MEDLINE | ID: mdl-28091817
ABSTRACT

BACKGROUND:

Teratomas of the cranial vault are divided into histopathological subtypes and grouped by prognoses mature (good prognosis), mixed/malignant and immature teratomas (intermediate prognosis). This schema also includes non-teratomatous tumors. The authors of this study sought to elucidate histologically dependent predictors of survival and further clarify the classification system of intracranial teratomas.

METHODS:

We performed a systematic analysis of the published literature to identify studies describing patients with intracranial teratomas diagnosed with magnetic resonance imaging (MRI) and presenting definite information on histologies, therapies, and outcomes at a minimum follow-up of 2 years. Disease-free (DFS) and overall survival (OS) were evaluated.

RESULTS:

A total of 18 articles comprised of 134 patients were included. On univariate analysis, male sex and gross-total resection (GTR) were associated with high mean DFS (p = 0.0362 and p < 0.0001, respectively). On multivariate analysis, mature teratomas located in the pineal, and those having undergone subtotal resection (STR) demonstrated high mean OS (p = 0.0023 and p = 0.0044, respectively). Mature and mixed/malignant suprasellar teratomas had equally higher mean OS versus immature suprasellar teratomas (p < 0.0001). Mature and immature teratomas treated with adjuvant therapy had significantly higher mean OS compared to those managed with surgery alone (p = 0.0421 and p = 0.0423, respectively). Males with immature teratomas had the highest mean OS (p < 0.0001). Immature teratomas managed with surgery alone had higher mean DFS, but lower mean OS, compared to those treated with adjuvant therapy (p = 0.0176 and p = 0.0423, respectively).

CONCLUSIONS:

Our data highlight the divergent nature of the different histopathological subtypes of teratomas, and suggest that survival outcomes are multifactorial. Specifically, male sex, pineal, suprasellar, GTR, and STR were dependent predictors of OS, while histopathology was an independent predictor of OS.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Teratoma / Neoplasias Encefálicas Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Female / Humans / Male Idioma: En Revista: Acta Neurochir (Wien) Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Teratoma / Neoplasias Encefálicas Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Female / Humans / Male Idioma: En Revista: Acta Neurochir (Wien) Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos