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A novel withanolide with an unprecedented carbon skeleton from Physalis angulata.
Sun, Cheng-Peng; Kutateladze, Andrei G; Zhao, Feng; Chen, Li-Xia; Qiu, Feng.
Afiliação
  • Sun CP; Tianjin State Key Laboratory of Modern Chinese Medicine and School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. fengqiu20070118@163.com and Department of Natural Products Chemistry, School of Traditional Chi
  • Kutateladze AG; Department of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208, USA.
  • Zhao F; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, China.
  • Chen LX; Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. syzyclx@163.com.
  • Qiu F; Tianjin State Key Laboratory of Modern Chinese Medicine and School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. fengqiu20070118@163.com and Department of Natural Products Chemistry, School of Traditional Chi
Org Biomol Chem ; 15(5): 1110-1114, 2017 Feb 01.
Article em En | MEDLINE | ID: mdl-28098317
A novel withanolide, aromaphysalin A (1), possessing an exceptional C(11)-C(15) bond and an unprecedented 4,9-cyclized aromatic ring (ring A), is isolated from stems and leaves of Physalis angulata L. Its structure was determined by a combination of HRESIMS, 2D NMR spectra, and theoretical calculations. Compound 1 exhibited inhibitory activity on NO production with an IC50 value of 51.64 µM. A plausible biosynthetic pathway for 1 is also discussed.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carbono / Physalis / Vitanolídeos / Óxido Nítrico Limite: Animals Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carbono / Physalis / Vitanolídeos / Óxido Nítrico Limite: Animals Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2017 Tipo de documento: Article