Biomaterials Made from Coiled-Coil Peptides.
Subcell Biochem
; 82: 575-600, 2017.
Article
em En
| MEDLINE
| ID: mdl-28101873
ABSTRACT
The development of biomaterials designed for specific applications is an important objective in personalized medicine. While the breadth and prominence of biomaterials have increased exponentially over the past decades, critical challenges remain to be addressed, particularly in the development of biomaterials that exhibit highly specific functions. These functional properties are often encoded within the molecular structure of the component molecules. Proteins, as a consequence of their structural specificity, represent useful substrates for the construction of functional biomaterials through rational design. This chapter provides an in-depth survey of biomaterials constructed from coiled-coils, one of the best-understood protein structural motifs. We discuss the utility of this structurally diverse and functionally tunable class of proteins for the creation of novel biomaterials. This discussion illustrates the progress that has been made in the development of coiled-coil biomaterials by showcasing studies that bridge the gap between the academic science and potential technological impact.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Materiais Biocompatíveis
/
Engenharia de Proteínas
Tipo de estudo:
Qualitative_research
Idioma:
En
Revista:
Subcell Biochem
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Geórgia