Brucella abortus 2308&#916;NodV&#916;NodW double-mutant is highly attenuated and confers protection against wild-type challenge in BALB/c mice.

Li, Zhiqiang; Wang, Shuli; Zhang, Jinliang; Yang, Guangli; Yuan, Baodong; Huang, Jie; Han, Jincheng; Xi, Li; Xiao, Yanren; Chen, Chuangfu; Zhang, Hui

Brucella abortus 2308ΔNodVΔNodW double-mutant is highly attenuated and confers protection against wild-type challenge in BALB/c mice.

Li, Zhiqiang; Wang, Shuli; Zhang, Jinliang; Yang, Guangli; Yuan, Baodong; Huang, Jie; Han, Jincheng; Xi, Li; Xiao, Yanren; Chen, Chuangfu; Zhang, Hui.

Afiliação

Li Z; School of Biotechnology and Food, Shangqiu Normal University, Shangqiu 476000, Henan, China.
Wang S; School of Biotechnology and Food, Shangqiu Normal University, Shangqiu 476000, Henan, China.
Zhang J; School of Biotechnology and Food, Shangqiu Normal University, Shangqiu 476000, Henan, China.
Yang G; School of Biotechnology and Food, Shangqiu Normal University, Shangqiu 476000, Henan, China.
Yuan B; School of Biotechnology and Food, Shangqiu Normal University, Shangqiu 476000, Henan, China.
Huang J; School of Biotechnology and Food, Shangqiu Normal University, Shangqiu 476000, Henan, China.
Han J; School of Biotechnology and Food, Shangqiu Normal University, Shangqiu 476000, Henan, China.
Xi L; School of Biotechnology and Food, Shangqiu Normal University, Shangqiu 476000, Henan, China.
Xiao Y; Institution of Forestry Bureau, Nangong 055750, Hebei, China.
Chen C; College of Animal Science and Technology, Shihezi University, Shihezi 832003, Xinjiang, China.
Zhang H; College of Animal Science and Technology, Shihezi University, Shihezi 832003, Xinjiang, China. Electronic address: allanzhh@sohu.com.

Microb Pathog ; 106: 30-39, 2017 May.

Article em En | MEDLINE | ID: mdl-28131952

Assuntos

Vacina contra Brucelose/imunologia; Brucella abortus/genética; Brucella abortus/imunologia; Brucelose/imunologia; Brucelose/prevenção & controle; Vacinas Atenuadas/imunologia; Animais; Anticorpos Antibacterianos/sangue; Anticorpos Antibacterianos/imunologia; Vacina contra Brucelose/genética; Brucelose/sangue; Brucelose Bovina/prevenção & controle; Bovinos; Citocinas/genética; Citocinas/metabolismo; Modelos Animais de Doenças; Feminino; Deleção de Genes; Imunoglobulina G/sangue; Imunoglobulina G/imunologia; Interferon gama/imunologia; Interferon gama/metabolismo; Interleucina-4/imunologia; Interleucina-4/metabolismo; Macrófagos/imunologia; Macrófagos/microbiologia; Camundongos; Camundongos Endogâmicos BALB C; Mutação; Células RAW 264.7; Proteínas Recombinantes/genética; Proteínas Recombinantes/imunologia; Baço/imunologia; Vacinas Atenuadas/genética; Virulência; Fatores de Virulência/genética

Palavras-chave

B. abortus 2308; Live attenuated vaccine; NodV; NodW

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Brucella abortus / Brucelose / Vacina contra Brucelose / Vacinas Atenuadas Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Microb Pathog Assunto da revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China

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