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Discovery of 2-((3-Acrylamido-4-methylphenyl)amino)-N-(2-methyl-5-(3,4,5-trimethoxybenzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chromosome (BMX) Kinase Inhibitor.
Liang, Xiaofei; Lv, Fengchao; Wang, Beilei; Yu, Kailin; Wu, Hong; Qi, Ziping; Jiang, Zongru; Chen, Cheng; Wang, Aoli; Miao, Weili; Wang, Wenchao; Hu, Zhenquan; Liu, Juan; Liu, Xiaochuan; Zhao, Zheng; Wang, Li; Zhang, Shanchuan; Ye, Zi; Wang, Chu; Ren, Tao; Wang, Yinsheng; Liu, Qingsong; Liu, Jing.
Afiliação
  • Liang X; High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Lv F; CHMFL-HCMTC Target Therapy Joint Laboratory , 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Wang B; High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Yu K; University of Science and Technology of China , Hefei, Anhui 230036, P. R. China.
  • Wu H; High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Qi Z; University of Science and Technology of China , Hefei, Anhui 230036, P. R. China.
  • Jiang Z; High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Chen C; University of Science and Technology of China , Hefei, Anhui 230036, P. R. China.
  • Wang A; High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Miao W; CHMFL-HCMTC Target Therapy Joint Laboratory , 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Wang W; High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Hu Z; CHMFL-HCMTC Target Therapy Joint Laboratory , 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Liu J; High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Liu X; University of Science and Technology of China , Hefei, Anhui 230036, P. R. China.
  • Zhao Z; High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Wang L; University of Science and Technology of China , Hefei, Anhui 230036, P. R. China.
  • Zhang S; High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Ye Z; University of Science and Technology of China , Hefei, Anhui 230036, P. R. China.
  • Wang C; Department of Chemistry, University of California-Riverside , 900 University Avenue, Riverside, California 92521, United States.
  • Ren T; High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Wang Y; CHMFL-HCMTC Target Therapy Joint Laboratory , 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Liu Q; High Magnetic Field Laboratory, Chinese Academy of Sciences , Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
  • Liu J; CHMFL-HCMTC Target Therapy Joint Laboratory , 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China.
J Med Chem ; 60(5): 1793-1816, 2017 03 09.
Article em En | MEDLINE | ID: mdl-28140585
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Benzamidas / Medula Óssea / Proteínas Tirosina Quinases / Inibidores de Proteínas Quinases Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Benzamidas / Medula Óssea / Proteínas Tirosina Quinases / Inibidores de Proteínas Quinases Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2017 Tipo de documento: Article