Parkinson's disease as a multisystem disorder.
J Neural Transm (Vienna)
; 124(6): 709-713, 2017 06.
Article
em En
| MEDLINE
| ID: mdl-28155133
ABSTRACT
This article summarises the noteworthy contribution of Professor Jellinger to the understanding of Parkinson's disease (PD) as a disease affecting multiple body- and neurotransmitter-systems. Phosphorylated alpha-synuclein and the formation of Lewy pathology as neuropathological hallmarks of PD seem to spread from the enteric nervous system and the olfactory bulb in a rostrocranial direction to the CNS. Subsequently, a progressive degeneration of the dopaminergic-nigrostriatal system and widespread extranigral pathology affecting different anatomical structures and neurotransmitters are induced causing the various non-motor and motor symptoms of PD.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Neural Transm (Vienna)
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Alemanha