Yaws Osteoperiostitis Treated with Single-Dose Azithromycin.
Am J Trop Med Hyg
; 96(5): 1039-1041, 2017 May.
Article
em En
| MEDLINE
| ID: mdl-28193743
ABSTRACT
AbstractThe etiologic agent of yaws, Treponema pallidum subsp. pertenue, causes a multistage infection transmitted by nonsexual contact with the exudates from active lesions. Bone lesions in the form of osteoperiostitis are common and occur in numerous bones simultaneously in early stages. Although a multinational eradication campaign with mass administration of intramuscular benzathine benzylpenicillin in the 1950s greatly reduced its global incidence, a resurgence of yaws has occurred since around 2000 in western and central Africa and the Pacific Islands. The finding that a single oral dose of azithromycin (30 mg/kg) was as effective as benzathine benzylpenicillin prompted renewed interest by World Health Organization in 2012 toward eradication of this infection by 2020. We previously reported the excellent response to benzathine benzylpenicillin therapy for yaws osteoperiostitis. Herein, we document a confirmed case of yaws with osteoperiostitis successfully treated with single-dose azithromycin and discuss the pathology of yaws periostitis and comment on the implications of this in light of the new campaign toward yaws eradication.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Periostite
/
Treponema pallidum
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Bouba
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DNA Bacteriano
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Azitromicina
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Antibacterianos
Limite:
Child, preschool
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Humans
/
Male
Idioma:
En
Revista:
Am J Trop Med Hyg
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Espanha