DL-3-n-Butylphthalide (NBP) Provides Neuroprotection in the Mice Models After Traumatic Brain Injury via Nrf2-ARE Signaling Pathway.

Liu, Zhengwei; Wang, Handong; Shi, Xiaofeng; Li, Liwen; Zhou, Mengliang; Ding, Hui; Yang, Youqing; Li, Xiang; Ding, Ke

Liu, Zhengwei; Wang, Handong; Shi, Xiaofeng; Li, Liwen; Zhou, Mengliang; Ding, Hui; Yang, Youqing; Li, Xiang; Ding, Ke.

Afiliação

Liu Z; Department of Neurosurgery, School of Medicine, Jinling Hospital, Southern Medical University (Guangzhou), 305 East Zhongshan Road, Nanjing, 210002, Jiangsu, People's Republic of China.
Wang H; Department of Neurosurgery, Shenzhen Longgang Central Hospital, 6082 Longgangdadao Road, Shenzhen, 518116, Guangdong, People's Republic of China.
Shi X; Department of Neurosurgery, School of Medicine, Jinling Hospital, Southern Medical University (Guangzhou), 305 East Zhongshan Road, Nanjing, 210002, Jiangsu, People's Republic of China. njhdwang@hotmail.com.
Li L; Department of Neurosurgery, Shenzhen Longgang Central Hospital, 6082 Longgangdadao Road, Shenzhen, 518116, Guangdong, People's Republic of China.
Zhou M; Department of Neurosurgery, School of Medicine, Jinling Hospital, Nanjing University, 305 East Zhongshan Road, Nanjing, 210002, Jiangsu, People's Republic of China.
Ding H; Department of Neurosurgery, School of Medicine, Jinling Hospital, Nanjing University, 305 East Zhongshan Road, Nanjing, 210002, Jiangsu, People's Republic of China.
Yang Y; Department of Neurosurgery, School of Medicine, Jinling Hospital, Southern Medical University (Guangzhou), 305 East Zhongshan Road, Nanjing, 210002, Jiangsu, People's Republic of China.
Li X; Department of Neurosurgery, School of Medicine, Jinling Hospital, Southern Medical University (Guangzhou), 305 East Zhongshan Road, Nanjing, 210002, Jiangsu, People's Republic of China.
Ding K; Department of Neurosurgery, School of Medicine, Jinling Hospital, Nanjing University, 305 East Zhongshan Road, Nanjing, 210002, Jiangsu, People's Republic of China.

Neurochem Res ; 42(5): 1375-1386, 2017 May.

Article em En | MEDLINE | ID: mdl-28214984

Assuntos

Benzofuranos/uso terapêutico; Lesões Encefálicas Traumáticas/metabolismo; Modelos Animais de Doenças; Fator 2 Relacionado a NF-E2/biossíntese; Fármacos Neuroprotetores/uso terapêutico; Transdução de Sinais/fisiologia; Animais; Benzofuranos/farmacologia; Lesões Encefálicas Traumáticas/patologia; Lesões Encefálicas Traumáticas/prevenção & controle; Masculino; Camundongos; Camundongos Endogâmicos ICR; Fármacos Neuroprotetores/farmacologia; Estresse Oxidativo/efeitos dos fármacos; Estresse Oxidativo/fisiologia; Distribuição Aleatória; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

DL-3-n-Butylphthalide; Mice model; Neuroprotection; Nrf2-ARE signaling pathway; Traumatic brain injury

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzofuranos / Transdução de Sinais / Fármacos Neuroprotetores / Modelos Animais de Doenças / Fator 2 Relacionado a NF-E2 / Lesões Encefálicas Traumáticas Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Neurochem Res Ano de publicação: 2017 Tipo de documento: Article

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