Expanding the product portfolio of fungal type I fatty acid synthases.
Nat Chem Biol
; 13(4): 360-362, 2017 04.
Article
em En
| MEDLINE
| ID: mdl-28218911
ABSTRACT
Fungal type I fatty acid synthases (FASs) are mega-enzymes with two separated, identical compartments, in which the acyl carrier protein (ACP) domains shuttle substrates to catalytically active sites embedded in the chamber wall. We devised synthetic FASs by integrating heterologous enzymes into the reaction chambers and demonstrated their capability to convert acyl-ACP or acyl-CoA from canonical fatty acid biosynthesis to short/medium-chain fatty acids and methyl ketones.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Saccharomyces cerevisiae
/
Basidiomycota
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Ácido Graxo Sintase Tipo I
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Ácidos Graxos
/
Cetonas
Idioma:
En
Revista:
Nat Chem Biol
Assunto da revista:
BIOLOGIA
/
QUIMICA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Suécia