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Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma.
Chandrawati, Rona; Chang, Jason Y H; Reina-Torres, Ester; Jumeaux, Coline; Sherwood, Joseph M; Stamer, W Daniel; Zelikin, Alexander N; Overby, Darryl R; Stevens, Molly M.
Afiliação
  • Chandrawati R; Department of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, UK.
  • Chang JYH; Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK.
  • Reina-Torres E; Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK.
  • Jumeaux C; Department of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, UK.
  • Sherwood JM; Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK.
  • Stamer WD; Department of Ophthalmology, Duke University School of Medicine, Durham, NC, 27710, USA.
  • Zelikin AN; Department of Chemistry and iNANO Interdisciplinary Nanoscience Center, Aarhus University, Aarhus C, 8000, Denmark.
  • Overby DR; Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK.
  • Stevens MM; Department of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, UK.
Adv Mater ; 29(16)2017 Apr.
Article em En | MEDLINE | ID: mdl-28221702
ABSTRACT
Nitric oxide (NO) is able to lower intraocular pressure (IOP); however, its therapeutic effects on outflow physiology are location- and dose-dependent. A NO delivery platform that directly targets the resistance-generating region of the conventional outflow pathway and locally liberates a controlled dose of NO is reported. An increase in outflow facility (decrease in IOP) is demonstrated in a mouse model.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Óxido Nítrico Limite: Animals Idioma: En Revista: Adv Mater Assunto da revista: BIOFISICA / QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Óxido Nítrico Limite: Animals Idioma: En Revista: Adv Mater Assunto da revista: BIOFISICA / QUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Reino Unido