Nanostructured polysaccharidic microcapsules for intracellular release of cisplatin.
Int J Biol Macromol
; 99: 187-195, 2017 Jun.
Article
em En
| MEDLINE
| ID: mdl-28232109
ABSTRACT
Carbohydrate polimeric microcapsules were assembled using a LbL approach onto a CaCO3 core. The microcapsules were used to delivery the anticancer drug cisplatin into HeLa and MCF-7 cancer cell lines. Drug encapsulation, measured by ICP spectroscopy, was around 50% of the charging solution. Fluorimetric measurements showed an efficient cellular uptake of polysacchardic microcapsules in both cell lines. The drug-loaded capsules demonstrated a better efficiency against cell viability than the free drug. Specifically, the amount of platinum reaching genomic DNA was measured, showing that encapsulation improves the nuclear delivery of the drug for both cell lines.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos
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Portadores de Fármacos
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Cisplatino
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Espaço Intracelular
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Nanoestruturas
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Liberação Controlada de Fármacos
Limite:
Humans
Idioma:
En
Revista:
Int J Biol Macromol
Ano de publicação:
2017
Tipo de documento:
Article