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Benzimidazole inhibitors from the Niclosamide chemotype inhibit Wnt/ß-catenin signaling with selectivity over effects on ATP homeostasis.
Mook, Robert A; Ren, Xiu-Rong; Wang, Jiangbo; Piao, Hailan; Barak, Larry S; Kim Lyerly, H; Chen, Wei.
Afiliação
  • Mook RA; Department of Medicine, Duke University Medical Center, Durham, NC 27710, United States. Electronic address: robert.mook@duke.edu.
  • Ren XR; Department of Medicine, Duke University Medical Center, Durham, NC 27710, United States.
  • Wang J; Department of Medicine, Duke University Medical Center, Durham, NC 27710, United States.
  • Piao H; Department of Medicine, Duke University Medical Center, Durham, NC 27710, United States.
  • Barak LS; Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, United States.
  • Kim Lyerly H; Department of Surgery, Duke University Medical Center, Durham, NC 27710, United States.
  • Chen W; Department of Medicine, Duke University Medical Center, Durham, NC 27710, United States. Electronic address: w.chen@dm.duke.edu.
Bioorg Med Chem ; 25(6): 1804-1816, 2017 03 15.
Article em En | MEDLINE | ID: mdl-28233680
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzimidazóis / Transdução de Sinais / Trifosfato de Adenosina / Proteínas Wnt / Beta Catenina / Niclosamida Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzimidazóis / Transdução de Sinais / Trifosfato de Adenosina / Proteínas Wnt / Beta Catenina / Niclosamida Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2017 Tipo de documento: Article