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Downregulation of E Protein Activity Augments an ILC2 Differentiation Program in the Thymus.
Wang, Hong-Cheng; Qian, Liangyue; Zhao, Ying; Mengarelli, Joni; Adrianto, Indra; Montgomery, Courtney G; Urban, Joseph F; Fung, Kar-Ming; Sun, Xiao-Hong.
Afiliação
  • Wang HC; Program in Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.
  • Qian L; Program in Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.
  • Zhao Y; Program in Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.
  • Mengarelli J; Program in Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.
  • Adrianto I; Program in Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.
  • Montgomery CG; Program in Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.
  • Urban JF; Diet, Genomics, and Immunology Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, United States Department of Agriculture, Beltsville, MD 20705; and.
  • Fung KM; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104.
  • Sun XH; Program in Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; sunx@omrf.org.
J Immunol ; 198(8): 3149-3156, 2017 04 15.
Article em En | MEDLINE | ID: mdl-28258196
Innate lymphoid cells (ILCs) are important regulators in various immune responses. The current paradigm states that all newly made ILCs originate from common lymphoid progenitors in the bone marrow. Id2, an inhibitor of E protein transcription factors, is indispensable for ILC differentiation. Unexpectedly, we found that ectopically expressing Id1 or deleting two E protein genes in the thymus drastically increased ILC2 counts in the thymus and other organs where ILC2 normally reside. Further evidence suggests a thymic origin of these mutant ILC2s. The mutant mice exhibit augmented spontaneous infiltration of eosinophils and heightened responses to papain in the lung and increased ability to expulse the helminth parasite, Nippostrongylus brasiliensis These results prompt the questions of whether the thymus naturally has the capacity to produce ILC2s and whether E proteins restrain such a potential. The abundance of ILC2s in Id1 transgenic mice also offers a unique opportunity for testing the biological functions of ILC2s.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Timo / Linfócitos / Diferenciação Celular / Células Progenitoras Linfoides / Imunidade Inata Limite: Animals Idioma: En Revista: J Immunol Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Timo / Linfócitos / Diferenciação Celular / Células Progenitoras Linfoides / Imunidade Inata Limite: Animals Idioma: En Revista: J Immunol Ano de publicação: 2017 Tipo de documento: Article