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Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer.
Medrano, Mauricio; Communal, Laudine; Brown, Kevin R; Iwanicki, Marcin; Normand, Josee; Paterson, Joshua; Sircoulomb, Fabrice; Krzyzanowski, Paul; Novak, Marian; Doodnauth, Sasha A; Saiz, Fernando Suarez; Cullis, Jane; Al-Awar, Rima; Neel, Benjamin G; McPherson, John; Drapkin, Ronny; Ailles, Laurie; Mes-Massons, Anne-Marie; Rottapel, Robert.
Afiliação
  • Medrano M; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.
  • Communal L; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC H2X 0A9, Canada; Institut du Cancer de Montréal, Montréal, QC H2X 0A9, Canada.
  • Brown KR; Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada.
  • Iwanicki M; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Normand J; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada.
  • Paterson J; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada.
  • Sircoulomb F; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada.
  • Krzyzanowski P; Ontario Institute for Cancer Research, MaRS Centre, Toronto, ON M5G 1L7, Canada.
  • Novak M; Department of Medical Oncology, Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
  • Doodnauth SA; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.
  • Saiz FS; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada.
  • Cullis J; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.
  • Al-Awar R; Ontario Institute for Cancer Research, MaRS Centre, Toronto, ON M5G 1L7, Canada.
  • Neel BG; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada; Laura and Isaac Perlmutter Cancer Centre, NYU Langone Medical Center, New York, NY 10016, USA.
  • McPherson J; Ontario Institute for Cancer Research, MaRS Centre, Toronto, ON M5G 1L7, Canada.
  • Drapkin R; Ovarian Cancer Research Center, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Ailles L; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.
  • Mes-Massons AM; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC H2X 0A9, Canada; Institut du Cancer de Montréal, Montréal, QC H2X 0A9, Canada; Département de Médecine, Université de Montréal, Montreal, QC H3T 1J4, Canada.
  • Rottapel R; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Medicine, University of Toronto, Toronto, ON M5G 2C4, Canada; Department of Immunology, University of Toronto,
Cell Rep ; 18(10): 2343-2358, 2017 03 07.
Article em En | MEDLINE | ID: mdl-28273451
The degree of genetic aberrations characteristic of high-grade serous ovarian cancer (HGSC) makes identification of the molecular features that drive tumor progression difficult. Here, we perform genome-wide RNAi screens and comprehensive expression analysis of cell-surface markers in a panel of HGSC cell lines to identify genes that are critical to their survival. We report that the tetraspanin CD151 contributes to survival of a subset of HGSC cell lines associated with a ZEB transcriptional program and supports the growth of HGSC tumors. Moreover, we show that high CD151 expression is prognostic of poor clinical outcome. This study reveals cell-surface vulnerabilities associated with HGSC, provides a framework for identifying therapeutic targets, and reports a role for CD151 in HGSC.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Biomarcadores Tumorais / Membrana Celular / Cistadenocarcinoma Seroso / Tetraspanina 24 Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: Cell Rep Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Biomarcadores Tumorais / Membrana Celular / Cistadenocarcinoma Seroso / Tetraspanina 24 Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: Cell Rep Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Canadá