Cardio-oncology Related to Heart Failure: Epidermal Growth Factor Receptor Target-Based Therapy.
Heart Fail Clin
; 13(2): 297-309, 2017 Apr.
Article
em En
| MEDLINE
| ID: mdl-28279416
ABSTRACT
Cancer therapy targeting the epidermal growth factor receptor (EGFR)/erythroblastic leukemia viral oncogene B (ErbB)/human EGFR receptor (HER) family of tyrosine kinases has been successfully used in treatment of several malignancies. The ErbB pathways play a role in the maintenance of cardiac homeostasis. This article summarizes current knowledge about EGFR/ErbB/HER receptor-targeted cancer therapeutics focusing on their cardiotoxicity profiles, molecular mechanisms, and implications in clinical cardio-oncology. The article discusses challenges in predicting, monitoring, and treating cardiac dysfunction and heart failure associated with ErbB-targeted cancer therapeutics and highlights opportunities for researchers and clinical investigators.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Inibidores de Proteínas Quinases
/
Insuficiência Cardíaca
/
Neoplasias
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Heart Fail Clin
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Estados Unidos