Superoxide-induced deimination of arginine in hematopoietic cells.
FEBS Lett
; 226(2): 285-6, 1988 Jan 04.
Article
em En
| MEDLINE
| ID: mdl-2828104
ABSTRACT
Murine bone marrow cells can produce citrulline directly from L-arginine without intermediate ornithine. An L-arginine-dependent biochemical pathway synthesizing L-citrulline and nitrate, coupled to an effector mechanism has also been recently demonstrated in murine cytotoxic activated macrophages. We show herein that L-citrulline synthesis in murine bone marrow cells can be induced by the generation of superoxide. It can take place in an arginine-free medium, suggesting the implication of a superoxide-dependent peptidyl arginine deiminase.
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Base de dados:
MEDLINE
Assunto principal:
Arginina
/
Células-Tronco Hematopoéticas
/
Superóxidos
Limite:
Animals
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
França