Matrix metalloproteinases and airway remodeling and function in primary ciliary dyskinesia.
Respir Med
; 124: 49-56, 2017 03.
Article
em En
| MEDLINE
| ID: mdl-28284321
ABSTRACT
BACKGROUND:
The balance between matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) is important in the regulation of airway damage.OBJECTIVE:
To evaluate whether they are important in the pathophysiology of primary and secondary ciliary dyskinesia (PCD, SCD).METHODS:
We measured sputum bacteriology, lung CT changes, MMPs, TIMPs and lung function in 86 patients (51 PCD, 35 SCD) in a cross-sectional study; the 10 controls studied did not have HRCT or sputum cultures. MMPs, TIMPs and lung function were evaluated longitudinally for up to one year in 38 PCD patients.RESULTS:
At baseline, there were no differences in MMPs, TIMPs and MMPs/TIMPs, between PCD and SCD but lower levels were found in controls. There was an association between poorer lung function with increasing levels of MMPs in PCD, while in SCD only MMP-9/TIMP-1 values correlated with FRC z-scores. Levels of MMPs and TIMPs significantly correlated with severity HRCT changes. Longitudinally, there were significant correlations between slope of changes in spirometric parameters and slope of change in sputum MMPs in PCD patients.CONCLUSIONS:
In conclusion, we report for the first time that increased MMPs are associated with worse airway damage in PCD and SCD, and thus are potential therapeutic targets.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Sistema Respiratório
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Síndrome de Kartagener
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Inibidor Tecidual de Metaloproteinase-1
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Metaloproteinases da Matriz
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Remodelação das Vias Aéreas
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Pulmão
Tipo de estudo:
Observational_studies
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Prevalence_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Respir Med
Ano de publicação:
2017
Tipo de documento:
Article