[Benign transient hyperphosphatasaemia in infants: Clinical series]. / Hiperfosfatasemia transitoria benigna de la infancia: Serie clínica.
Rev Chil Pediatr
; 88(1): 169-175, 2017 Feb.
Article
em Es
| MEDLINE
| ID: mdl-28288234
ABSTRACT
Alkaline Phosphatase (ALP) is a group of 4 isoenzymes produced in different tissues. Elevated levels of ALP can be developed under physiological conditions, and can indicate the presence of bone or hepatobiliary diseases. In children, one of its most common harmless causes is benign transient hyperphosphatasaemia (BTH), a little known condition. The objective is to report BTH cases and propose a monitoring plan. CASE REPORTS The cases of 5 children aged between 11 and 50 months are presented, 4 of them female, with the incidental finding of a sudden and severe ALP elevation (> 1,000 U/l), in tests ordered due to either abnormal growth and development, or intercurrent infections. Bone and liver disease were ruled out using the patient history, physical examination and basic laboratory results. Isoenzymes levels were determined in 2 patients. A return to normal ALP levels was observed over a period of 1-6 months, with no evidence of further complications. CONCLUSION:
BTH is a benign self-limiting biochemical disorder, which should be considered in children under 5 years old with severe ALP elevation in the absence of clinical or laboratory abnormalities suggestive of bone or liver disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Ósseas
/
Fosfatase Alcalina
/
Hepatopatias
Tipo de estudo:
Observational_studies
Limite:
Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
Es
Revista:
Rev Chil Pediatr
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Chile