Systems Biology of Metabolism.
Annu Rev Biochem
; 86: 245-275, 2017 06 20.
Article
em En
| MEDLINE
| ID: mdl-28301739
ABSTRACT
Metabolism is highly complex and involves thousands of different connected reactions; it is therefore necessary to use mathematical models for holistic studies. The use of mathematical models in biology is referred to as systems biology. In this review, the principles of systems biology are described, and two different types of mathematical models used for studying metabolism are discussed kinetic models and genome-scale metabolic models. The use of different omics technologies, including transcriptomics, proteomics, metabolomics, and fluxomics, for studying metabolism is presented. Finally, the application of systems biology for analyzing global regulatory structures, engineering the metabolism of cell factories, and analyzing human diseases is discussed.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Modelos Estatísticos
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Genoma
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Biologia de Sistemas
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Metabolômica
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Transcriptoma
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Modelos Biológicos
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Annu Rev Biochem
Ano de publicação:
2017
Tipo de documento:
Article