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Highly efficient biallelic genome editing of human ES/iPS cells using a CRISPR/Cas9 or TALEN system.
Takayama, Kazuo; Igai, Keisuke; Hagihara, Yasuko; Hashimoto, Rina; Hanawa, Morifumi; Sakuma, Tetsushi; Tachibana, Masashi; Sakurai, Fuminori; Yamamoto, Takashi; Mizuguchi, Hiroyuki.
Afiliação
  • Takayama K; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan.
  • Igai K; PRESTO, Japan Science and Technology Agency, Saitama 332-0012, Japan.
  • Hagihara Y; K-CONNEX, Kyoto University, Kyoto 606-8302, Japan.
  • Hashimoto R; Laboratory of Hepatocyte Regulation, National Institute of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan.
  • Hanawa M; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan.
  • Sakuma T; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan.
  • Tachibana M; Laboratory of Biochemistry and Molecular Biology, School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan.
  • Sakurai F; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan.
  • Yamamoto T; Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Hiroshima 739-8526, Japan.
  • Mizuguchi H; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan.
Nucleic Acids Res ; 45(9): 5198-5207, 2017 May 19.
Article em En | MEDLINE | ID: mdl-28334759
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Genoma Humano / Alelos / Células-Tronco Pluripotentes Induzidas / Sistemas CRISPR-Cas / Células-Tronco Embrionárias Humanas / Nucleases dos Efetores Semelhantes a Ativadores de Transcrição / Edição de Genes Limite: Humans Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Japão
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Genoma Humano / Alelos / Células-Tronco Pluripotentes Induzidas / Sistemas CRISPR-Cas / Células-Tronco Embrionárias Humanas / Nucleases dos Efetores Semelhantes a Ativadores de Transcrição / Edição de Genes Limite: Humans Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Japão