An aromatic amino acid within intracellular loop 2 of the prostaglandin EP2 receptor is a prerequisite for selective association and activation of G&#945;s.

Yano, Akiko; Takahashi, Yuko; Moriguchi, Hiromi; Inazumi, Tomoaki; Koga, Tomoaki; Otaka, Akira; Sugimoto, Yukihiko

An aromatic amino acid within intracellular loop 2 of the prostaglandin EP2 receptor is a prerequisite for selective association and activation of Gαs.

Yano, Akiko; Takahashi, Yuko; Moriguchi, Hiromi; Inazumi, Tomoaki; Koga, Tomoaki; Otaka, Akira; Sugimoto, Yukihiko.

Afiliação

Yano A; Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Takahashi Y; Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Moriguchi H; Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Inazumi T; Department of Pharmaceutical Biochemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan; AMED-CREST, Tokyo 100-0004, Japan.
Koga T; Priority Organization for Innovation and Excellence, Kumamoto University, Kumamoto, Japan.
Otaka A; Department of Bioorganic Synthetic Chemistry, Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, Japan.
Sugimoto Y; Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan; Department of Pharmaceutical Biochemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan; AMED-CREST, Tokyo 100-0004, Japan. Electronic address: ysugi

Biochim Biophys Acta Mol Cell Biol Lipids ; 1862(6): 615-622, 2017 Jun.

Article em En | MEDLINE | ID: mdl-28336329

Assuntos

Cromograninas/metabolismo; Subunidades alfa Gs de Proteínas de Ligação ao GTP/metabolismo; Receptores de Prostaglandina E Subtipo EP2/metabolismo; Substituição de Aminoácidos; Animais; Cromograninas/química; Cromograninas/genética; Cricetinae; Subunidades alfa Gs de Proteínas de Ligação ao GTP/química; Subunidades alfa Gs de Proteínas de Ligação ao GTP/genética; Humanos; Mutação de Sentido Incorreto; Domínios Proteicos; Estrutura Secundária de Proteína; Receptores de Prostaglandina E Subtipo EP2/química; Receptores de Prostaglandina E Subtipo EP2/genética

Palavras-chave

Eicosanoid; G protein-coupled receptor; Heterotrimeric G protein; Prostaglandin; Prostanoid receptor; Receptor structure-function

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cromograninas / Subunidades alfa Gs de Proteínas de Ligação ao GTP / Receptores de Prostaglandina E Subtipo EP2 Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Biochim Biophys Acta Mol Cell Biol Lipids Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Japão

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