A plant-derived dehydrorotenoid: a new inhibitor of hepatitis C virus entry.
FEBS Lett
; 591(9): 1305-1317, 2017 05.
Article
em En
| MEDLINE
| ID: mdl-28337741
ABSTRACT
Emergence of drug-resistant viruses, high cost and adverse side-effects associated with the standard therapy against hepatitis C virus (HCV) infection demonstrate the need for development of well tolerated and effective antivirals. We identified and chemically characterised the dehydrorotenoid boeravinone H, isolated from the herb Boerhavia diffusa, as a new inhibitor of HCV entry. The compound significantly inhibits the binding and entry of hepatitis C-like particles (HCV-LPs) in hepatoma cells in vitro with no apparent cytotoxicity. Boeravinone H inhibits the initial phase of HCV entry probably by acting directly on the viral particle. Importantly, the compound prevents HCV entry and infection in cell culture (ex vivo). Thus, boeravinone H is a potential antiviral agent for the prevention and control of HCV infection.
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Base de dados:
MEDLINE
Assunto principal:
Flavonoides
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Extratos Vegetais
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Hepacivirus
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Internalização do Vírus
Limite:
Humans
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Índia