The impact of maternal obesity on inflammatory processes and consequences for later offspring health outcomes.
J Dev Orig Health Dis
; 8(5): 529-540, 2017 Oct.
Article
em En
| MEDLINE
| ID: mdl-28343461
ABSTRACT
Obesity is a global epidemic, affecting both developed and developing countries. The related metabolic consequences that arise from being overweight or obese are a paramount global health concern, and represent a significant burden on healthcare systems. Furthermore, being overweight or obese during pregnancy increases the risk of offspring developing obesity and other related metabolic complications in later life, which can therefore perpetuate a transgenerational cycle of obesity. Obesity is associated with a chronic state of low-grade metabolic inflammation. However, the role of maternal obesity-mediated alterations in inflammatory processes as a mechanism underpinning developmental programming in offspring is less understood. Further, the use of anti-inflammatory agents as an intervention strategy to ameliorate or reverse the impact of adverse developmental programming in the setting of maternal obesity has not been well studied. This review will discuss the impact of maternal obesity on key inflammatory pathways, impact on pregnancy and offspring outcomes, potential mechanisms and avenues for intervention.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Complicações na Gravidez
/
Resultado da Gravidez
/
Mediadores da Inflamação
/
Desenvolvimento Fetal
/
Obesidade
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
J Dev Orig Health Dis
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Nova Zelândia